Does borderzone contrast enhancement on intraoperative MRI during high grade glioma resection correlate with residual tumor?

Recruiting

• Conditions: high grade glioma; malignant brain tumor; 10029211

• Registration Number: NL-OMON31501
• Lead Sponsor: Academisch Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

- supratentorial brain tumor, on contrast enhanced MRI suspect for a high grade glioma
- indication for resection of the tumor
- age >= 18 years
- WHO Performance Scale <= 2
- ASA class <= 3
- good knowledge of the Dutch language
- informed consent

Exclusion Criteria

- recurrent tumor
- multiple tumor localizations
- prior radiotherapy on the skull
- prior chemotherapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The relation between the shape and size of contrast enhancement on<br /><br>intraoperative MRI at the resection cavity border, and the presence of residual<br /><br>tumor tissue. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* The relation between possible contrast enhancement and contrast enhancing<br /><br>tissue volume on the last intraoperative MRI scan and the early diagnostic MRI<br /><br>scan (within 72 hours after surgery).<br /><br>* Postoperative clinical condition (WHO Performance Scale).<br /><br>* Survival (Kaplan Meier)</p><br>