Hydromorphone as an adjuvant induction agent in reducing rocuronium induced pain and hemodynamic changes during tracheal intubatio

Not Applicable

Completed

• Conditions: rocuronium induced pain; hemodynamic stability during induction; nil; Anaesthesiology - Anaesthetics

• Registration Number: ACTRN12610000316000
• Lead Sponsor: Chul Joong Lee, M.D., Ph.D.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-04-20
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Ages between 20-70 yr, American Society of Anesthesia (ASA) physical status I or II and undergoing general anesthesia for elective gastric and colorectal surgery from August 2008 to January 2009

Exclusion Criteria

Known allergy to opioids, diabetes mellitus, asthma, neurological deficit, pregnancy or patients who had received analgesics or sedatives within the previous 24 h

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in rocuronium induced withdrawal movement. The two investigators were educated beforehand to grade the patient response according to the scale proposed by Shevchenko and colleagues 12: 1 = no movement, 2 = movement at the wrist only, 3 = movement/withdrawal involving the arm only (elbow/shoulder), 4 = generalized response, withdrawal or movement in more than one extremity.[Thirty seconds after administering the study drug, anesthesia was induced with 2.5% thiopental sodium 5 mg/kg. After the loss of consciousness, rocuronium 0.6 mg/kg was injected, and immediate withdrawal movements were recorded.]

Secondary Outcome Measures

Name	Time	Method
attenuation of hemodynamic profile (Mean arterial pressure, MAP. Heart rate, HR) during tracheal intubation[Two minutes after rocuronium injection, the tracheal intubation was performed and the hemodynamic changes were observed. The mean arterial pressure (MAP) and heart rate (HR) were measured upon arrival at the operating room, 1 min before and after tracheal intubation. The MAPs were measured by noninvasive blood pressure manometer and HRs were measured by using electrocardiograms.]