Circuit-level mechanisms of cerebral compensation in Parkinson's disease

Completed

Conditions: eye movements
Parkinson's disease
10028037

Registration Number: NL-OMON40985

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Trial is onging in other countries

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 46

Inclusion Criteria

A person with Parkinson's disease must meet the following:
- Idiopathic Parkinson*s disease according to UK brain bank criteria.
- Mild to moderate disease severity (Hoehn and Yahr 1-3).
- Dopaminergic therapy with a clear clinical response of non-tremor symptoms (bradykinesia, rigidity).
- Right-handed
- Normal/corrected-to-normal vision;A control subject must meet the following:
- right handed
- normal / corrected to normal vision
- and be considered healthy

Exclusion Criteria

- Epilepsy, convulsion or seizure (TMS)
- Serious head trauma or brain surgery
- Large or ferromagnetic metal parts in the head (except for a dental wire)
- Implanted cardiac pacemaker or neurostimulator
- Pregnancy
- Familial epilepsy
- Any other exclusion as per TMS screening form
- Neurological or psychiatric co-morbidity (e.g. stroke, depression).
- Severe head tremor or dyskinesias
- cognitive impairment (MMSE < 26)
- General MRI exclusion criteria (e.g. pacemaker, implanted metal parts, deep brain stimulation, claustrophobia).
- Skin diseases at intended electrode sites (EMG)
- Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation
- disorders of vision

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main behavioural parameters will be the differences in eye movement<br /><br>behaviours depending on cTBS condition (Arm 1) and cTBS and TMS single-pulse<br /><br>timing (early versus late with respect to an eye-movement) (Arm 2). The main<br /><br>neurobiological parameters will be differences in fMRI activation patterns in<br /><br>oculomotor regions depending on cTBS location (Arm 1), and changes in cerebral<br /><br>blood flow after cTBS (Arm 2). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>In Arm 1, the secondary study parameters will be differences in fMRI activation<br /><br>patterns in a larger oculomotor circuit. Additionally, we will assess any<br /><br>changes in tremor-related activity following cTBS. In Arm 2, we will more<br /><br>precisely examine the TMS pulse timings on eye-movement behavior. </p><br>