Brain plasticity and functional recovery in low-functioning stroke patients trained with a dynamic hand orthosis: a MRI pilot study

Completed

Conditions: hemiparesis
impaired arm-hand function due to a stroke
10028037

Registration Number: NL-OMON43523

Lead Sponsor: Adelante

Brief Summary: Trial is onging in other countries

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 5

Inclusion Criteria

Stroke patients:
• Chronic unilateral supratentorial stroke;
• Post-stroke time > 12 months;
• Age >= 18 years;
• Severely impaired arm-hand function (AHF): Utrechtse Arm-hand Test (UAT) score 0-1;
• Ability to comprehend the test and measurement instructions (in Dutch).;Healthy persons:
- age >=18 years
- no history of stroke
- no impaired arm-hand function
- able to comprehend the test and measurement instructions in Dutch.

Exclusion Criteria

CVA patienten:
• Severe cognitive impairments;
• Spasticity in the affected arm-hand: Modified Ashworth Scale (MAS) score >=2;
• Severe additional orthopaedic, rheumatoid, neurologic impairments of the body that may *further impede arm-hand task execution;
• No informed consent. ;• MRI contra-indications: epilepsy, claustrophobia, medication, metal parts in the body (metal plates or screws, clips on blood vessels, braces, metal wire behind teeth, prostheses, piercings, tattoos (including permanent makeup), artificial cardiac valve, anticonception spiral, metal splinters, pacemaker, insulin pump, other electronic devices)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>a) Motor performance level (FM, ARAT, ABILHAND);<br /><br>b) Hand motor performance and brain activation patterns during task<br /><br>performance (fMRI);<br /><br>c) Reaction time / movement time (button-press task);<br /><br>d) Grip force<br /><br>e) Somatosensory hand performance (fMRI);<br /><br>f) T1-weighted anatomical scans and resting state scans (fMRI).</p><br>

Secondary Outcome Measures