Brain Imaging and Cognition in Adults living with Duchenne Muscular Dystrophy
- Conditions
- Duchenne Muscular Dystrophy / Duchenne10028302
- Registration Number
- NL-OMON52255
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Trial is onging in other countries
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Group A: DMD patients, MRI and NPE
Group B: controls, MRI and NPE
Group C: DMD patients, NPE
For group A/C:
Able to provide written informed consent
Age 18 years or older
Genetically confirmed diagnosis for DMD
Male
For group B:
Able to provide written informed consent
Age: maximally one year apart from a DMD participant (expected to be between
18-30 years old)
Male
A potential subject who meets any of the following criteria will be excluded
from participation in this study in group A:
- MRI contraindications
- Inability to complete the NPE
A potential subject who meets any of the following criteria will be excluded
from participation in this study in group B:
- A diagnosis for any neurological or neuropsychological disorder
- MRI contraindications
- Inability to complete the NPE
A potential subject who meets any of the following criteria will be excluded
from participation in this study in group C:
- Inability to complete the NPE
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameters/endpoints: Presence or absence or significant differences<br /><br>in brain volumes structural connectivity, cerebral perfusion and functional<br /><br>connectivity between patients and healthy controls with respect to age, after<br /><br>applying the appropriate statistics per measure. Neurocognitive parameters and<br /><br>behavioural functioning will be assessed to describe the cohorts.</p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>