One-step autologous cartilage regeneration versus two-step autologous chondrocyte implantation: A randomized controlled trial evaluating clinical, radiological and patient related outcomes
Not Applicable
Recruiting
- Conditions
- M23.99
- Registration Number
- DRKS00026196
- Lead Sponsor
- Abteilung und Poliklinik für Sportorthopädie, Klinikum rechts der Isar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Symptomatic cartilage defect of the knee (size 2.5-6 cm), Focal defect grade 3 or 4 according to the International Cartilage Repair Society (ICRS)
Exclusion Criteria
Systemic disease (Rheumatic disease, Diabetes etc.), Previous surgeries at the cartilage, menisci or ligaments of the knee, History of fractures or osteotomies of the lower extremities
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Knee Injury and Osteoarthritis Outcome Score (KOOS; questionnaire) after 24 months
- Secondary Outcome Measures
Name Time Method KOOS after 6 and 12 months, IKDC-Score after 6, 12 and 24 months, Tegner activity score after 6, 12 and 24 months, quantitative and qualitative MRI evaluation (MOCART-Score) after 12 months