The Danish Childhood Obesity Biobank

Not Applicable

Recruiting

• Conditions: Metabolic Disease; Obesity; NAFLD, Non-alcoholic Fatty Liver Disease; Cardiovascular Diseases
• Interventions: Behavioral: A family-centered, multidisciplinary obesity treatment program

• Registration Number: NCT00928473
• Lead Sponsor: Zealand University Hospital

Brief Summary

The Danish Childhood Obesity Biobank aims to produce a scientific platform for research in obesity: Bio-clinical data are collected from two cohorts - an obesity clinic cohort and a population-based cohort. The biobank thus facilitates translation between research and clinical practice of obesity treatment and related complications.

Detailed Description

The Danish Childhood Obesity Biobank collects data from two cohorts - an obesity clinic cohort and a population-based cohort, of which the latter functions as a reference group.

The biobank continuously and longitudinally includes clinical data and biological samples from children and adolescents in obesity treatment. The population-based cohort has been recruited in a cross-sectional manner from Danish schools, high schools, and dentistries.

Data included in the biobank include venous blood samples, stool, urine, saliva, anthropometrics, body composition by dual-energy X-ray absorptiometry, magnetic resonance imaging and spectroscopy, and genetic markers among others. The data are stored in a central secured electronic database and biological materials are stored in -80-degree Celsius freezers until analyses.

To date, the Danish Childhood Obesity Biobank have included data from more than 5250 children, adolescents and adults from the obesity clinic cohort and more than 4200 from the population-based cohort.

Study Timeline

• Study Start: 2009-01
• Study First Submitted: 2009-06-25
• Study First Submitted QC: 2009-06-25
• Study First Posted: 2009-06-26
• Status Verified: 2020-11
• Last Update Submitted: 2020-11-09
• Last Update Posted: 2020-11-12
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• 2- 100 Years old
• Adipose, BMI > 90 % percentile

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Lifestyle counseling	A family-centered, multidisciplinary obesity treatment program	The obese children will start a treatment for obesity in the Children's Obesity Clinic. This treatment includes lifestyle counseling, objective examination, weight-controls, visiting a psychologist, visiting a dietician and blood samples, DXA-scan, eventually MRI.

Primary Outcome Measures

Name	Time	Method
Weightloss, changes in blood parameters and in fatty liver developement.	continuously

Trial Locations

Locations (1)

The Children's Obesity Clinic, Paediatric department, University Hospital Holbæk, Region Zealand; 🇩🇰 Holbæk, Denmark