Randomized controlled trial of desflurane vs. sevoflurane in pediatric liver transplant patients (liver des-sev)

Not Applicable

• Conditions: Pediatric patients who are scheduled for living donor liver transplantation

• Registration Number: JPRN-jRCTs031180416
• Lead Sponsor: Yukimasa Sho

Brief Summary

In the anaesthetic management of paediatric living donor liver transplant surgery, we investigated the effect of anaesthetic maintenance drugs on extubation on the day of surgery in two groups: those maintained with sevoflurane and those maintained with desflurane. There was no difference in the rate of extubation on the day of surgery between sevoflurane and desflurane.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-22
• Study Completion: 2021-06-03
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

1) patients who are scheduled for living donor liver transplantation at National Center for Child Health and Development, Tokyo, Japan; 2) patients weighted more than or equal to 6kg; 3) patients aged less than 16 years old; 4) patients whose informed consent is obtained from their guardians before operation

Exclusion Criteria

1) preoperative ICU management; 2) other organ complications caused by diseases other than the present liver illness; 3) allergy to either/both of inhalation anesthetic(s) or halogenated agents; 4) past history of malignant hyperthermia or family history of malignant hyperthermia; 5) metabolic disease; 6) acute liver failure; 7) pulmonary hypertension; 8) respiratory tract symptoms within 2 weeks before surgery; 9) asthma; 10) any cases inappropriate for the trial judged by surgeons or anesthesiologists in charge

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ratio of operating room extubation after pediatric living donor liver transplantation

Secondary Outcome Measures

Name	Time	Method
1) Length of postoperative intubation <br>2) Length of Intensive care unit stay <br>3) Perioperative blood examination <br>4) Perioperative vital sign change <br>5) Perioperative infusion therapy volume <br>6) Perioperative urine output change <br>7) Ratio of postoperative infection <br>8) Ratio of postoperative rejection