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Clinical Trials/NCT07336342
NCT07336342
Completed
Not Applicable

Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open Pilot

Massachusetts General Hospital1 site in 1 country12 target enrollmentStarted: November 15, 2024Last updated:
InterventionsQuiet Focus

Overview

Phase
Not Applicable
Status
Completed
Enrollment
12
Locations
1
Primary Endpoint
The Credibility and Expectancy Questionnaire

Overview

Brief Summary

The goal of this clinical trial is to pilot an adaptation of mindfulness-based cognitive therapy for chronic pain and depression. The main questions it aims to answer in a later fully powered randomized controlled trial are:

  • Is an adaptation of mindfulness-based cognitive therapy for older Black adults able to improve quality of life?
  • Will an adapted mindfulness based cognitive therapy reduce pain interference to a greater degree than a traditional health enhancement program?

Detailed Description

Co-morbid chronic pain-depression is common among older Black adults and this co-morbidity worsens physical and emotional function. Access to evidence based non-pharmacological management is limited. Mindfulness based cognitive therapy (MBCT) is an evidence-based, non-pharmacological intervention that could address the chronic pain-depression co-morbidity among older Black adults, but it requires tailoring. The proposed study will establish the feasibility, acceptability and credibility of Quiet Focus, a cultural adaptation of MBCT aimed at the chronic pain-depression co-morbidity among older Black adults in the community.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Other
Masking
None

Eligibility Criteria

Ages
50 Years to 120 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Participant Inclusion Criteria
  • Older adult (age ≥ 50)
  • All individuals who identify with one or more nationalities or ethnic groups originating in any of the Black racial groups of Africa
  • Pain in muscles, joints, bones, or associated soft tissues (NRS\>4) lasting longer than 3 months
  • Depressed (PHQ-9 score of 5-14)
  • English fluency/literacy
  • Ability and willingness to participate via in-person and video
  • No change to type or dose of antidepressant medications for at least 6 weeks prior to screening
  • Willing to provide informed consent and comply with all aspects of the protocol
  • Participant

Exclusion Criteria

  • Moderately severe or severe depressive symptoms (PHQ-9 ≥ 15)
  • Current substance abuse/dependence
  • Significant cognitive impairment
  • History of more than 8 sessions of cognitive-behavioral therapy
  • History of previous training in mindfulness or undergoing counseling more than once a month
  • History of or current diagnosis of psychosis
  • Active suicidal ideation (PHQ-9 item #9 or otherwise reported during screening) or self-harm within the past 90 days
  • Current participation in another behavioral clinical trial

Arms & Interventions

Quiet Focus

Experimental

Intervention: Quiet Focus (Behavioral)

Outcomes

Primary Outcomes

The Credibility and Expectancy Questionnaire

Time Frame: From enrollment to 3 months from the end of treatment at 8 weeks

This scale measures participant expectations around the study's positive outcomes, with measures ranging from 0 (not at all expected) to 9 (extremely expected). A higher score indicate greater trust in the study design and an openness to potential benefits.

The Client Satisfaction Questionnaire

Time Frame: Administered at the end of treatment at 8 weeks and at the three month follow up visit.

Three item scale measuring patient satisfaction with the program. Scores for each item range from 1 (unsatisfied) to 4 (very satisfied).

Modified Patient Global Impression of Change

Time Frame: At end of 8 week program (post test) and again at 3 month follow up visit.

Measures participant impressions of overall change with one being very much improved and eight being very much worse. Lower scores indicate improvement.

Secondary Outcomes

  • Numerical Rating Scale(From enrollment to 3 months from the end of treatment at 8 weeks.)
  • PROMIS Physical Function(From enrollment to 3 months from the end of treatment at 8 weeks)
  • PROMIS Anxiety(From enrollment to 3 months from the end of treatment at 8 weeks)
  • PROMIS Depression(From enrollment to 3 months from the end of treatment at 8 weeks)
  • PROMIS Emotional Support(From enrollment to 3 months from the end of treatment at 8 weeks.)
  • Measure of Current Status Part A(From enrollment to 3 months from the end of treatment at 8 weeks)
  • Cognitive and Affective Mindfulness Scale-Revised(From enrollment to 3 months from the end of treatment at 8 weeks)
  • Chronic Pain Acceptance Questionnaire(From enrollment to 3 months from the end of treatment at 8 weeks)
  • Pain Self-Efficacy Questionnaire(From enrollment to 3 months from the end of treatment at 8 weeks)
  • Pain Catastrophizing Scale(From enrollment to 3 months from the end of treatment at 8 weeks)
  • Tampa Kinesiophobia Scale(From enrollment to 3 months from the end of treatment at 8 weeks)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Tony V. Pham, MD

Principal Investigator and Psychiatrist

Massachusetts General Hospital

Study Sites (1)

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