Oral and Systemic aMMP-8 in Periodontal Disease
Completed
- Conditions
- Periodontal DiseasesPeriodontal Inflammation
- Interventions
- Other: Biochemical analysis
- Registration Number
- NCT04268381
- Lead Sponsor
- Aydin Adnan Menderes University
- Brief Summary
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 83
Inclusion Criteria
- systemically healthy and non-smoker individuals aged 25 to 50 years
- having ≥20 teeth present (except third molars)
- individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses
Exclusion Criteria
- having any systemic disease
- smoking
- pregnancy or lactation
- using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy (n=23) Biochemical analysis - Gingivitis (n=20) Biochemical analysis - Periodontitis (n=40) Biochemical analysis -
- Primary Outcome Measures
Name Time Method Oral (GCF and saliva) and serum levels of aMMP-8 in periodontitis and gingivitis through study completion, an average of 4 months aMMP-8 levels
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Aydin Adnan Menderes University
🇹🇷Aydın, Turkey