Comparison Between Multimodal and Unimodal Analgesia in Cholecystectomy
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Sponsor
- October 6 University
- Enrollment
- 95
- Locations
- 2
- Primary Endpoint
- Postoperative visual analogue scale (VAS)
Study Overview
Brief Summary
Many surgical procedures are accompanied by postoperative pain with severity moderate, severe or extreme and insufficient postoperative pain control may cause risk of post-surgical complications and risk of chronic post-surgical pain The targets of preoperative pain management are to relieve patient suffering, reduce length of hospital stay and achieve early mobilization after surgery, decreasing opioid consumption and its side effects that are constipation, nausea, vomiting, dizziness, respiratory depression which is the most feared complication being life-threatening and some less common side effects as sedation
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing laparoscopic cholecystectomy
- •Patients older than 18 years old
Exclusion Criteria
- •Renal or hepatic or cardiac impairment patients
- •Patients with chronic pain history
- •Allergic patients after taking aspirin or other NSAIDs
- •patients with active gastrointestinal bleeding, ulcer and inflammatory bowel diseases or cerebrovascular bleeding
Arms & Interventions
multimodal
pregabalin/ acetaminophen/ celecoxib
Intervention: Pregabalin 150mg (Drug)
multimodal
pregabalin/ acetaminophen/ celecoxib
Intervention: Acetaminophen 1 G Oral Tablet (Drug)
multimodal
pregabalin/ acetaminophen/ celecoxib
Intervention: Celecoxib 400Mg Oral Capsule (Drug)
unimodal
Pregabalin
Intervention: Pregabalin 150mg (Drug)
Outcomes
Primary Outcomes
Postoperative visual analogue scale (VAS)
Time Frame: 24 hour postoperative
The visual analog scale (VAS) is a simple and often used method for evaluating variations in pain intensity.
Amount of post operative Needed opioid analgesia
Time Frame: 24 hour postoperative
ampules of opioid analgesia needed after operation
Secondary Outcomes
- Type and amount of prescribed post operative non opioid analgesia(24 hour postoperative)
Investigators
engy wahsh
head of clinical pharmacy unit
October 6 University