Influence of JAK inhibitors on the disease-associated network of intestinal immune cells in ulcerative colitis

• Conditions: Inflammatory Bowel Diseases; Ulcerative Colitis; 10017969; 10003816

• Registration Number: NL-OMON51787
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

ulcerative colitis
indication for JAK inhibitor

Exclusion Criteria

Age

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Observing changes in molecular and cellular patterns in the biopsies and blood<br /><br>upon JAK inhibition using a multi-omics approach.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Which (pre-existing or treatment-related) molecular and cellular patterns<br /><br>correlate with response to treatment or lack thereof?<br /><br>2. Are there differences between systemic (PMBCs) or local (biopsy) effects<br /><br>upon JAK inhibition?<br /><br>3. What are the long term effects of JAK inhibition on the immunological<br /><br>environment (week 52)</p><br>