Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
Not Applicable
Completed
- Conditions
- Dexmedetomidine
- Interventions
- Other: control
- Registration Number
- NCT03234660
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
Neuroapoptosis is induced by the administration of anesthetic agents to the young brain. Recent studies showed that the a2-adrenoceptor agonist, dexmedetomidine plays a trophic role during development and is neuroprotective in several settings of neuronal injury in animals. We hypothesized that neuroprotective effect of dexmedetomidine would be associated with evidence of brain injury detected by elevation of plasma concentration of glial fibrillary acid protein in children undergoing general anesthesia.
- Detailed Description
GFAP measure
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- children undergoing general anesthesia longer than 3 hours
Exclusion Criteria
- past history of anesthesia
- cardiopulmonary bypass
- preexisting neurocognitive dysfunction
- abnormalities of liver profile (aspartate transaminase > 40 unit/L, alanine aminotransferase > 40 unit/L)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control control placebo infusion Dexmedetomidine Dexmedetomidine Hydrochloride dexmedetomidine infusion
- Primary Outcome Measures
Name Time Method Glial fibrillary acid protein change from baseline glial fibrillary acid protein at 3 hours after the anesthetic induction plasma was collected at the given specific time
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
SNUH
🇰🇷Seoul, Jongro Gu, Korea, Republic of