The effects of dexmedetomidine on cerebral autoregulation and cerebral oxygenation in subarachnoid haemorrhage patients.

• Conditions: This study will be conducted on aneurysmal subarachnoid hemorrhage patients.; Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]

• Registration Number: EUCTR2012-000068-11-FI
• Lead Sponsor: Turku University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04-25
• Last Update Posted: 23 May 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

All patients with aneurysmal SAH after aneurysmal treatment (coiling or clipping) in the ICU of Turku University Hospital will be considered eligible for the study. 15 SAH patients requiring sedation and mechanical ventilation are enrolled in to the study.
1.SAH due to ruptured aneurysm
2.Aneurysm treated with coils or clip(s).
3.Age 18-80
4.Written informed consent from the next of kin.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 10
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 5

Exclusion Criteria

Preoperative
1.Pregnancy
2.Nursing woman
3.Sick sinus syndrome
4.Carotid stenosis (contraindication for dynamic autoregulation study)

During dexmedetomidine infusion
1.Sinus arrest
2.Increased ICP refractory to treatment

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified