Study to check the effect of drug called Dexmedetomidine on blood flow regulation to brain in patients having brain tumour
- Conditions
- Health Condition 1: null- neurologically stable patients
- Registration Number
- CTRI/2014/10/005148
- Lead Sponsor
- Sri Chitra Tirunal Institute for Medical Science and Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
two groups (15 patients in each group)
Group I - patients with unilateral Glioma, Glascow coma scale 15, American society of anesthesiology Grading 1 and 2.
Group II - patients having no intracranial pathology ( patients posted for lumbar and thoracic spinal cord surgeries (laminectomy, discectomy), American society of anesthesiology Grading 1 and 2.
Patient refusal, American society of Anesthesiology (ASA) class 3 and above, Age less than 18 years and more than 35 years, Preoperative Glasgow coma scale (GCS) <15, Intracranial vascular abnormalities, Documented cases of Carotid stenosis, atherosclerosis, Infra tentorial / posterior fossa tumours, Emergency surgery, Preoperative heart rate <50 bpm, Systemic hypertension stage III & above, Heart block, Known allergy to Dexmedetomidine, Patient on beta blockers, Coronary artery disease, Left ventricular dysfunction,Pregnant or Nursing woman.
Antihypertensive medication with alpha-methyldopa, clonidine or other a2-adrenergic agonist, Vascular pathology ( Plaque, calcification, narrowing, stenosis, abnormal flow pattern ) identified during pre-induction sonography, Difficulty in localizing intracranial vasculature by TCCDI, Abnormal bone window, Participation in another drug study during the preceding 1 month period.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method