The effects of dexmedetomidine on cerebral blood flow and cerebral metabolic rate
Not Applicable
Completed
- Conditions
- Traumatic brain injury (TBI), cerebral blood flow (CBF) and cerebral metabolic rate (CMR)Injury, Occupational Diseases, PoisoningIntracranial injury, unspecified
- Registration Number
- ISRCTN57998533
- Lead Sponsor
- Shanghai Sixth People's Hospital (China)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
1. Electrocardiogram (ECG) examination was normal, no hypotension, no bradycardia, etc
2. Written informed consent
Exclusion Criteria
1. Brain tumor, hypertensive cerebral hemorrhage and non-traumatic brain injury patients
2. Patients combined heart failure, liver dysfunction, renal insufficiency, cardiac arrhythmias
3. Patients combined severe primary liver disease, severe primary renal disease, severe primary hematopoietic system diseases or mental illness
4. Pregnancy or breastfeeding women
5. Patients with allergies
6. Patients participating in other clinical trials
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral blood flow
- Secondary Outcome Measures
Name Time Method 1. Cerebral metabolic rate of oxygen<br>2. The dosage of dopamine<br>3. Diastolic blood pressure<br>4. Systolic blood pressure<br>5. Mean arterial pressure<br>6. Heart rate<br>7. Respiratory rate<br>8. Oxygen saturation <br>9. PaCO2