The Prevalence and Treatment of Sleep Disorders in Lung Transplant Recipients With BOS 2 & 3 and the Influence on Quality of Life and Daytime Activity.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Bronchiolitis Obliterans
- Sponsor
- The Prince Charles Hospital
- Locations
- 1
- Primary Endpoint
- To Measure Prevalence of sleep disorders in Bronchiolitis Obliterans 2&3 patients
- Status
- Withdrawn
- Last Updated
- 5 years ago
Overview
Brief Summary
This study is to determine whether sleep disorders contribute to impaired quality of life and mobility in patients with Bronchiolitis Obliterans syndrome and whether non invasive positive airways pressure ventilation can improve sleep, quality of life and mobility in this patient group.
Detailed Description
Patients with Bronchiolitis Obliterans syndrome (BOS) 2 \& 3 (25) will be matched 1:2 BOS 0 patients with similar demographics such as age, gender, BMI, time post transplant and renal dysfunction.Patients fitting inclusion/exclusion criteria once they have given informed consent will complete questionnaires on quality of life (QOL), any sleep issues they may have and be assessed by a doctor. Data from standard blood tests, respiratory function tests and physio assessments of daytime activity, mobility and muscle strength will be collected. All participants will undergo an overnight sleep study. If a sleep disorder is identified the participant will be offered appropriate treatment. All assessments with the exception of the sleep study will be repeated at 6 and 12 months post sleep study.
Investigators
Anne Carle
Dr A. Fiene & Dr J Douglas
The Prince Charles Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients who are post lung, heart lung and heart lung liver transplant with bronchiolitis obliterans 2 \& 3
- •Comparative group -Patients who are post lung, heart lung and heart lung liver transplant with bronchiolitis obliterans 0
- •Identified possible sleep related disorder
Exclusion Criteria
- •Subjects who do not provide informed consent
- •Subjects unable to understand the study and related procedures
- •Patients with a life expectancy of less than 6 months
Outcomes
Primary Outcomes
To Measure Prevalence of sleep disorders in Bronchiolitis Obliterans 2&3 patients
Time Frame: 12 months
Using level one laboratory based polysomnograph
Secondary Outcomes
- Quality of life assessment using Rand SF36 standard survey(Baseline, 6 and 12 months after sleep study)