Emergency Laparotomies and Outcomes During the COVID-19 Pandemic - a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- 30-day mortality
研究概览
简要总结
NLR has previously been observed to correlate with complications in upper GI (1) and colorectal (2) surgery. The investigators sought to assess if a similar correlation can be identified in emergency general surgical patients and if the presence of suspected or confirmed COVID-19 may impact on this.
Given the heterogeneity of emergency general surgery the investigators therefore plan to perform a retrospective review of patients having emergency laparotomies only at a single NHS site during COVID-19 pandemic. Assessment of outcomes and Neutrophil:lymphocyte ratio as a predictor of outcomes will be completed. Outcomes will be completed in line with the recent COVIDSurg study criteria (3). The primary outcome is 30-day mortality. Secondary outcomes are 7-day mortality, re-operation, length of stay, post-operative respiratory failure, post-operative ARDS (Acute Respiratory Distress Syndrome), post-operative sepsis and ITU (Intensive Therapy Unit)/HDU (High Dependency Unit) admission.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing emergency laparotomy (change made due to heterogeneity of emergency general surgery)
排除标准
- •Inherited or acquired immunodeficiency (which may directly skew NLR)
结局指标
主要结局
30-day mortality
时间窗: 30 days
Mortality
次要结局
- Number of participants returning to theatre(30 days)
- Length of stay(30 days)
- Post-operative respiratory failure(30 days)
- Post-operative ARDS(30 days)
- ITU/HDU admission(30 days)
- 7-day mortality(7 days)
- Post-operative sepsis(30 days)
研究者
Nader Habib Bedwani
Doctor
Barking, Havering and Redbridge University Hospitals NHS Trust