Effect of intranasal dexmedetomidine on laryngoscopic pressor response andintraoperative hemodynamic changes under general anesthesia: A double blindedrandomized placebo controlled trial.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Heart rate, Blood Pressure & Oxygen saturation
研究概览
简要总结
Intranasal dexmedetomidine reduces laryngoscopic pressor response and maintain better perioperative hemodynamics when used as premedication.
1.Intranasal Dexmedetomidine is more effective in comparison with intranasal normal saline on attenuation of laryngoscopic response and maintaining hemodynamic stability during general
anaesthesia.
2.Intranasal Dexmedetomidine has good analgesic effect and better recovery in post operative period
研究设计
- 研究类型
- Interventional
- 分配方式
- Stratified block randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients belongs to 18 to 60 years of age
- •ASA I, ASA II (American Society of Anesthesiologist classification)
- •Patients undergoing endotracheal intubation in elective surgery under General anesthesia
- •Duration of surgery lasting less than 3 hours.
排除标准
- •Patients undergoing Emergency surgeries
- •Anticipated difficult airway
- •Reduced cardiopulmonary reserve
- •Patient on beta blockers
- •Previous nasal surgery
- •Laparoscopic surgery
- •Laryngoscopy attempts more than 2 times.
结局指标
主要结局
Heart rate, Blood Pressure & Oxygen saturation
时间窗: A baseline heart rate, blood pressure & oxygen saturation will be measured before | administration of the study drug, then at the time of administration and 10 mins once until the time | of scheduled intubation. | â–ª Post intubation vitals are measured at 1,2,3,4,5 & every 10 minutes until end of surgery.
次要结局
- Ramsay sedation score(visual analog score)