Effect of a drug "dexmedetomidine" to prevent rise in blood pressure on general anesthesia

Phase 4

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/08/056218
• Lead Sponsor: Pondicherry institute of medical science

Brief Summary

Intranasal dexmedetomidine reduces laryngoscopic pressor response and maintain better perioperative hemodynamics when used as premedication.



1.Intranasal Dexmedetomidine is more effective in comparison with intranasal normal saline on attenuation of laryngoscopic response and maintaining hemodynamic stability during general

anaesthesia.

2.Intranasal Dexmedetomidine has good analgesic effect and better recovery in post operative period

Detailed Description

Not available

Study Timeline

• Study Start: 2023-07-08
• Last Update Posted: 2023-07-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients belongs to 18 to 60 years of age 2.
• ASA I, ASA II (American Society of Anesthesiologist classification) 3.
• Patients undergoing endotracheal intubation in elective surgery under General anesthesia 4.
• Duration of surgery lasting less than 3 hours.

Exclusion Criteria

• Patients undergoing Emergency surgeries 2.
• Anticipated difficult airway 3.
• Reduced cardiopulmonary reserve 4.
• Patient on beta blockers 5.
• Previous nasal surgery 6.
• Laparoscopic surgery 7.
• Laryngoscopy attempts more than 2 times.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart rate, Blood Pressure & Oxygen saturation	A baseline heart rate, blood pressure & oxygen saturation will be measured before | administration of the study drug, then at the time of administration and 10 mins once until the time | of scheduled intubation. | â–ª Post intubation vitals are measured at 1,2,3,4,5 & every 10 minutes until end of surgery.

Secondary Outcome Measures

Name	Time	Method
Ramsay sedation score	visual analog score

Trial Locations

Locations (1)

Department of Anesthesiology , Pondicherry Institute of Medical Sciences Hospital; 🇮🇳 Pondicherry, PONDICHERRY, India

Department of Anesthesiology , Pondicherry Institute of Medical Sciences Hospital

🇮🇳Pondicherry, PONDICHERRY, India

Dr Arun kumar A N

Principal investigator

9159281914

arunkumar.arunbala@gmail.com