effect of dexmedetomidine during general surgery

Phase 4

Recruiting

• Conditions: endotracheal intubation

• Registration Number: CTRI/2013/07/003820
• Lead Sponsor: Dept of Anaesthesiology

Brief Summary

Pressure response to laryngoscopy and intubation, resulting in stimulation of sympathetic nervous system leads to tachycardia and hypertension.Elevated plasma concentration of catecholamines due to sympathetic discharge increases HR,BP and myocardial oxygen demand, which may lead to haemodynamic instability. This response may be blunted by benzodiezepins,beta-blockers,opioids,nitroglycerine,etc.

Alpha2 receptor agonists may also be used for this purpose,with reducing the dose requirement of general anaesthetic agents. Dexmedetomidine is the selective and potent alpha2 agonist.

The aim of our study the effect of Dexmedetomidine on controlling the haemodynamic response to laryngoscopy and intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-07-26
• Last Update Posted: 2013-07-17

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients posted for elective surgery under general anaesthesia requiring endotracheal intubation.
• ASA physical status I and II.
• BMI ≤ 25kg/m2.
• Informed written consent for participation in study.

Exclusion Criteria

• Patients with diabetes, renal disease, cardiac diseases like IHD, Hypertension.
• Patients on drugs, having effects on heart rate and blood pressure (sedatives, opioids, β blockers, calcium channel blockers) and anti-psychiatric drugs.
• Pregnant women and lactating mothers.
• Anticipated difficult intubation.
• Intubation attempt lasting longer than 20 seconds.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blunting in haemodynamic stress response during laryngoscopy and intubation.	Blood pressure,heart rate,oxygen saturation are recorded starting from baseline to infusion and then upto 30 minutes after intubation.

Secondary Outcome Measures

Name	Time	Method
Sedative effect after infusion.	Sedation score will be recorded baseline and then after infusion of drug till induction.

Trial Locations

Locations (1)

Sir T.Hospital,Bhavnagar,Gujarat; 🇮🇳 Bhavnagar, GUJARAT, India

Sir T.Hospital,Bhavnagar,Gujarat

🇮🇳Bhavnagar, GUJARAT, India

DrNaveen Kumar Gour

Principal investigator

9825636161

drgour2@gmail.com