Diabetes Resolution and Hormone Changes After BPDLL and LSG
- Conditions
- Diabetes Mellitus
- Registration Number
- NCT01481675
- Lead Sponsor
- University of Patras
- Brief Summary
To evaluate and compare prospectively the effects of Biliopancreatic Diversion Long Limb (BPDLL) and Laparoscopic Sleeve Gastrectomy (LSG) on resolution of diabetes mellitus type 2.
- Detailed Description
Twelve patients with diabetes mellitus type 2 (DM 2) and body mass index (BMI)\> 50kg/m2) will undergo BPDLL and 12 twelve patients with DM 2 and BMI 40-50 kg/m2 will undergo LSG. The patients will be evaluated before and 1, 3 and 12 months after surgery with an oral glucose tolerance test. The investigators aim to investigate the effects of surgery on diabetes resolution, hypertension, dyslipidemia, and also on fasting, and glucose-stimulated insulin, glucagon, ghrelin, peptide-YY and glucagon-like peptide-1 (GLP-1) responses during during an oral glucose tolerance test (OGTT). Resolution of diabetes mellitus will be evaluated according to the criteria of American Diabetes Association with an OGTT. The effects on appetite and satiety will be also evaluated with the use of visual analog scores.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- BMI>50kg/m2 to undergo BPDLL
- BMI 40-50kg/m2 to undergo LSG
- Diabetes mellitus type 2
- Chronic medical illness
- Psychiatric illness
- Substance abuse
- Previous gastrointestinal surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diabetes resolution at 12 months after surgery 12 months after surgery
- Secondary Outcome Measures
Name Time Method Changes in PYY response to glucose 12 months after surgery Weight loss at 12 months after surgery 12 months after surgery Changes of GLP-1 response to glucose 12 months after surgery Changes in ghrelin levels 12 months after surgery
Trial Locations
- Locations (1)
University Hospital of Patras
🇬🇷Rion, Achaia, Greece