Effect of xanthones extract from mangosteen on reduced insulin resistance, visceral fat, and fatty liver due to reduction of inflammatory markers and oxidative stress in pre-diabetes/diabetes patients
Phase 3
- Conditions
- Xanthones extract,Pre-diabetes,type 2 diabetes,Insulin resistance,Obesity,fatty liver,metabolic profiles,lipid profiles
- Registration Number
- TCTR20151215003
- Lead Sponsor
- ational Research Council of Thailand (NRCT)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
prediabetes patients, type 2 diabetes patients
Exclusion Criteria
type 1 diabetes
renal failure with serum creatinine 2 0 md dL
secondary cause of chronic hepatitis
Liver failure with AST and ALT over than 2.5 times of upper limit
heavy alcoholic drinking
receiving anti hyperglycemic drugs TZD DDP IV inhibitor insulin GLP 1 agonist and antihyperlipid drugs fenofibrate gemfibrozile and ezetrol
receiving other herbal
secondary cause of hyperglycemia
history of inflammatory and infection diseases
pregnancy women
history of gall stone or cholecystectomy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method metabolic profiles, FBG, HbA1c, lipid profiles, insulin resistance, visceral fat and fatty liver 1 year t-test
- Secondary Outcome Measures
Name Time Method inflammatory markers and oxidative stress markers 1 year t-test