Influence of Exercise/Cardiorespiratory Fitness on Enhanced Endothelial Function With Aging: Role of Mitochondrial-derived Oxidative Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- Ball State University
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Change in vascular endothelial function
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.
Investigators
Brad Fleenor
Associate Professor
Ball State University
Eligibility Criteria
Inclusion Criteria
- •Resting brachial blood pressure \<160 mmHg (systolic)/\<100 mmHg (diastolic)
- •Body mass index ≤ 35 kg/m2
- •Nonsmoker
- •Women must be postmenopausal defined as cessation of menses ≥ 1 year.
Exclusion Criteria
- •cardiovascular/metabolic medications
- •known clinical disease
- •absolute contraindications to exercise testing
Outcomes
Primary Outcomes
Change in vascular endothelial function
Time Frame: Baseline and Post 1 hour
Brachial artery flow-mediated dilation (% \[relative\] and mm \[absolute\])
Secondary Outcomes
- Change in carotid artery Young's elastic modulus(Baseline and Post 1 hour)
- Change in carotid artery compliance(Baseline and Post 1 hour)
- Change in carotid artery stiffness - beta-stiffness index(Baseline and Post 1 hour)
- Change in cardiovascular function(Baseline and Post 1 hour)
- Change in Aortic Stiffness(Baseline and Post 1 hour)
- Change in carotid artery distensibility(Baseline and Post 1 hour)