Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

Not Applicable

Completed

• Conditions: Endothelial Dysfunction; Arterial Stiffness
• Interventions: Other: Acute submaximal exercise

• Registration Number: NCT06163456
• Lead Sponsor: Towson University

Brief Summary

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only \~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-12-02
• Primary Completion: 2020-03-15
• Status Verified: 2023-11
• Study Completion: 2023-11-29
• Study First Submitted: 2023-11-30
• Study First Submitted QC: 2023-11-30
• Last Update Submitted: 2023-11-30
• Study First Posted: 2023-12-08
• Last Update Posted: 2023-12-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• 18-29 years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week.

Exclusion Criteria

• currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol >200 mg/dl, low-density lipoprotein cholesterol >130 mg/dl, high-density lipoprotein cholesterol < 35 mg/dl, fasting glucose >100 mg/dl, systolic blood pressure > 130 mmHg, diastolic blood pressure >90 mmHg, and BMI >30 kg/m2.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
high fitness	Acute submaximal exercise	-
moderate fitness	Acute submaximal exercise	-
low fitness	Acute submaximal exercise	-

Primary Outcome Measures

Name	Time	Method
endothelial function	Baseline and 60 min post-exercise	flow-mediated dilation
arterial stiffness	Baseline and 60 min post-exercise	augmentation index

Trial Locations

Locations (1)

Towson University; 🇺🇸 Towson, Maryland, United States