NCT01410149已完成不适用
The Influence of Mode and Patient-ventilator Interaction on Sleep Quality in the ICU
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Sleep quality
研究概览
简要总结
Patients requiring mechanical ventilation in the ICU will undergo three consecutive nights of polysomnography to record sleep patterns while receiving three modes of mechanical ventilation; Proportional assist ventilation (PAV), Pressure support ventilation (PSV), Assist control ventilation (ACV), applied in random order. The purpose is to determine the effect of mode of mechanical ventilation on patient-ventilator asynchrony and sleep quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-75
- •received mechanical ventilation >72 hours
- •glasgow coma scale >10
- •acute physiology score <13
- •ready for partial ventilatory support: intact respiratory drive, PaO2/FiO2 ratio >200 on positive end expiratory pressure (PEEP) less than or equal to 5 cmH2O, and PH of 7.35 to 7.45
- •sedation: analgesia at dose not higher than 0.01 mg/kg/hr morphine equivalent x 48 hours, sedation at dose not higher than 0.01 mg/kg/hr lorazepam equivalent x 72 hours.
- •anticipate ongoing need for partial ventilatory support for the following 72 hours
排除标准
- •Successful completion of spontaneous breathing trial
- •Neurological injury, encephalopathy or abnormal EEG
- •History of central sleep apnea
- •General anaesthesia within 72 hours from study entry
- •Requiring haloperidol >10 mg/24 hours
- •hemodynamically unstable
结局指标
主要结局
Sleep quality
时间窗: 3 nights
Sleep fragmentation (number of arousals and awakenings/hr sleep), sleep architecture (% time asleep spent in Stage 1, 2, 3/4 and REM sleep)
次要结局
- Patient-ventilator asynchrony(3 nights)
研究者
Karen Bosma
Principal Investigator
Lawson Health Research Institute
研究点 (2)
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