Ventilator Mode and Respiratory Physiology
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Pulmonary Disease
- Sponsor
- University of California, San Diego
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Excess tidal volume
- Status
- Enrolling by Invitation
- Last Updated
- last year
Overview
Brief Summary
Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.
Investigators
Alex Pearce
Principal Investigator
University of California, San Diego
Eligibility Criteria
Inclusion Criteria
- •Admitted to ICU with acute respiratory failure
- •On adaptive pressure control mode of ventilation
- •Tidal volumes set between 5-8 cc/kg ideal body weight
Exclusion Criteria
- •Current use of neuromuscular blockade
- •Inability to obtain consent from patient or surrogate decision maker
- •Treating clinician refusal
Outcomes
Primary Outcomes
Excess tidal volume
Time Frame: From enrollment to end of monitoring at 4 hours
Exhaled tidal volume greater than 2cc/kg ideal body weight above intended or set tidal volume