Are topical or oral ibuprofen equally effective for the treatment of chronic knee pain in older people?

Department of Health (UK)0 个研究点目标入组 283 人开始时间: 2003年4月25日最近更新: 2015年1月13日

适应症

试验速览

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•1. Aged 50 or over
•2. Have ever had pain in or around the knee on most days for at least a month and have experienced knee pain for more than three months out of the preceding year
•3. General Practitioner (GP) consultation, or treatment, for knee pain in the preceding three years
•4. Informed consent
•5. Agreement to use chosen or allocated treatment
•6. GP agreement to prescribe oral/topical ibuprofen
•7. Ability to complete postal questionnaires

•1. Peptic ulceration (past or current)
•2. Current moderate or severe indigestion
•3. Previous severe adverse reaction to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
•4. Hypertension (systolic Blood Pressure [BP] of 155 mmHg or more or a diastolic BP of 105 mmHg or more)
•5. Uncontrolled heart failure
•6. Creatinine greater than 140 mmol/L
•7. Abnormal liver function sufficient to contraindicate use of NSAIDs (as liver function tests performed and reference ranges vary between different laboratories, this decision is at the discretion of the participant's GP)
•8. GP request not to include
•9. Serious psychological or psychiatric disorders (including dementia)
•10. Previous knee replacement/s or awaiting knee surgery
•11. Inflammatory arthropathy
•12. Pain referred from hip or back
•13. Serious injury within six months
•14. Currently on anticoagulants or oral steroids
•15. Anaemia (Haemoglobin [Hb] less than 12.4 g/L for men or less than 11.8 g/L for women)
•16. Disseminated malignancy
•To meet the American College of Rheumatologists (ACR) clinical criteria for osteoarthritis of the knee, patients need to have knee pain, as defined for this study, and meet three out of the following six criteria:
•1. Aged over fifty
•2. Less than 30 minutes morning stiffness
•3. Crepitus
•4. Bony tenderness
•5. Bony enlargement
•6. No palpable warmth

发起方

Department of Health (UK)