Comparison of Bananas and Gatorade on Performance and Exercise-induced Inflammation, Oxidative Stress, and Changes in Immune Function in Endurance Athletes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Appalachian State University
- Enrollment
- 14
- Locations
- 2
- Primary Endpoint
- Performance and fuel substrate utilization as measured through metabolomics
Study Overview
Brief Summary
This study compared the acute effect of ingesting bananas (BAN) versus a 6% carbohydrate drink (CHO) on 75-km cycling performance and post-exercise inflammation, oxidative stress, and innate immune function using traditional and metabolomics-based profiling.
Detailed Description
Trained cyclists (N=14) completed two 75-km cycling time trials (randomized, crossover) while ingesting BAN or CHO (0.2 g/kg carbohydrate every 15 min). Pre-, post-, and 1-h-post-exercise blood samples were analyzed for glucose, granulocyte (GR) and monocyte (MO) phagocytosis (PHAG) and oxidative burst activity, nine cytokines, F2-isoprostanes, ferric reducing ability of plasma (FRAP), and metabolic profiles using gas chromatography-mass spectrometry.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Ages 18-45 years
- •Cyclists, road racing experience.
- •Willing to avoid the use of supplements, herbs, medications during the study.
Exclusion Criteria
- •Over the age of 45 years
- •No cycling racing experience
- •Using supplements and medications during the study
Outcomes
Primary Outcomes
Performance and fuel substrate utilization as measured through metabolomics
Time Frame: Up to 6 months
Will measure shifts in metabolites following 75-km cycling while ingesting bananas or 6% carbohydrate beverage. The shift in metabolites will be assessed using GC-MS. Time frame from date of randomization until the last samples are collected and analyzed will be up to six months.
Secondary Outcomes
- Exercise-induced inflammation.(up to 6 months)
Investigators
David C. Nieman
Professor, Director of the Human Performance Lab
Appalachian State University