NCT01038726CompletedNot Applicable
Neural Effects of Exercise, Cognitive, or Combined Training in AD At-Risk Elders
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- The Cleveland Clinic
- Enrollment
- 108
- Locations
- 1
- Primary Endpoint
- Brain activation patterns measured by functional MRI
Study Overview
Brief Summary
The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 60 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •First or Second-degree relative of someone with Alzheimer's Disease
- •Not currently engaging in regular exercise
- •Able to undergo an MRI
- •Fluent in English
Exclusion Criteria
- •Neurological illnesses/conditions
- •Medical illness/conditions that may affect brain function
- •Any unstable or severe cardiovascular disease or asthmatic condition
- •Severe depressive symptoms
- •Inability to walk unassisted
Arms & Interventions
Combined Cognitive/Exercise Training
Active Comparator
Intervention: Exercise Training (Other)
Combined Cognitive/Exercise Training
Active Comparator
Intervention: Cognitive Training (Other)
Cognitive Training
Active Comparator
Intervention: Cognitive Training (Other)
Combined Low Intensity Training
Active Comparator
Intervention: Flexibility Training (Other)
Combined Low Intensity Training
Active Comparator
Intervention: Educational Sessions (Other)
Exercise Training
Active Comparator
Intervention: Exercise Training (Other)
Outcomes
Primary Outcomes
Brain activation patterns measured by functional MRI
Time Frame: baseline and 12 weeks
Secondary Outcomes
- Neuropsychological Testing(baseline and 12 weeks)
- Exercise assessment(baseline and 12 weeks)
Investigators
Study Sites (1)
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