Optimizing (breathing) techniques for radiotherapy of esophageal and lung carcinomas; a pilot study.
Completed
- Conditions
- Esophageal- and lung carcinomas1001799010029107
- Registration Number
- NL-OMON43647
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
• Histologically proven esophageal cancer (adeno-, or squamous cell
carcinoma) of the mid or distal esophagus or stage III Non-Small Cell Lung Cancer (NSCLC) (any histological subtype).
• Scheduled for external-beam photon radiotherapy with curative intention.
• WHO 0-2
• Age >= 18 years
• Written informed consent.
Exclusion Criteria
• Serious respiratory distress
• Noncompliance with any of the inclusion criteria.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Dose to the heart (mean heart dose, MHD), dose to the lungs (mean lung dose,<br /><br>MLD), robustness parameters (homogeneity index; coverage of clinical target<br /><br>volume).</p><br>
- Secondary Outcome Measures
Name Time Method <p>• Other DVH parameters of the heart (V5, V10, V20, V30, V40, V50, V60)<br /><br>• DVH parameters of specific subunits of the heart<br /><br>• ITV margin (margin for breathing movement defined as ITV - GTV)<br /><br>• Lung dose (mean lung dose (MLD, V5, V10, V20, V30, V40, V50, V60)<br /><br>• Position of the heart in relation to the target volumes<br /><br>• Lung volume<br /><br>• NTCP pulmonary toxicity<br /><br>• (NTCP heart toxicity) </p><br>