Ex vivo LPS stimulation in healthy and compromised subjects - Ex vivo LPS stimulation study

TNO0 个研究点目标入组 36 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•- aged 35 to 45 years, on study day 1
•- Healthy voluenteers are defined based on medical history evaluation, physical examination, results of the pre-study laboratory tests and a health and lifestyle questionnaire, with following criteria: HbA1c <= 5.5% (37 mmol/mol) or fasting glucose >= 3.4 and <= 5.6 mmol/L ; further the waist circumference < 94 cm; and body fat percentage between 8-24.9%.
•-The prediabetics with overweight meet the following criteria: HbA1c in the range of 6.0 - 6.5% (42 - 48mmol/mol) Or fasting glucose in the range of 6.1-6.9 mmol/L; further the waist circumference >= 102 cm; and body fat percentage >= 25 %.

•-Having a history of medical or surgical events that may significantly affect the study outcome, including any psychiatric history, and metabolic or endocrine disease, or any gastro-intestinal disorder or inflammatory diseases;
•-Use of any medication 14 days before day 01; use of paracetamol 7 days before day 01.
•-Currently smoking or stopped smoking less than 6 months ago
•-Alcohol consumption >= 21 units per week
•-Exercise more than five hours per week
•-Use of dietary supplements (e.g. fish oil capsules, polyphenols and vitamins)

发起方

TNO