Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Early Phase 1
Not yet recruiting
- Conditions
- Agitation, Emergence
- Interventions
- Registration Number
- NCT05264077
- Lead Sponsor
- Sheikh Zayed Medical College
- Brief Summary
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression but also helps in weaning for early extubation,give hemodynamic stability and reduce morbidity and mortality in icu..
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
- all patients with age <60 irrespective of gendre
Read More
Exclusion Criteria
- Patients who refuse to give consent, severely altered conscious level (GCS < 8/15), traumatic injury causing hypoxemia e.g., severe head / chest / facial trauma or pneumothorax, severe pneumonia, arrhythmia, impaired hearing or blindness, severe hepatic or renal disease, on neuromuscular blocking agents, recent myocardial infarction, use of anti-psychotics, hypersensitivity to any of the drug under study.
Read More
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dexmedetomidine Dexmedetomidine Hydrochloride Inj.Dexmedetomidine(precidex ) 200mcg/2ml Given to participants in infusion form for 24 hours Midazolam Dexmedetomidine Hydrochloride Inj.midazolam 5mg/ml given to participants in infusion form for 24 hrs
- Primary Outcome Measures
Name Time Method Effective sedation in icu patients lead to successful 1weaning in icu patients Upto 48 hrs Assess patients by using ramsay sedation score (score 1 =awake upto score 6=no response)
- Secondary Outcome Measures
Name Time Method