Efficacy of Dexmedetomidine Versus Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
Overview
- Phase
- Early Phase 1
- Intervention
- Dexmedetomidine Hydrochloride
- Conditions
- Agitation, Emergence
- Sponsor
- Sheikh Zayed Medical College
- Enrollment
- 66
- Primary Endpoint
- Effective sedation in icu patients lead to successful 1weaning in icu patients
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression but also helps in weaning for early extubation,give hemodynamic stability and reduce morbidity and mortality in icu..
Investigators
Momal Jaleel Khan
Dr.Momal jaleel khan
Sheikh Zayed Medical College
Eligibility Criteria
Inclusion Criteria
- •all patients with age \<60 irrespective of gendre
Exclusion Criteria
- •Patients who refuse to give consent, severely altered conscious level (GCS \< 8/15), traumatic injury causing hypoxemia e.g., severe head / chest / facial trauma or pneumothorax, severe pneumonia, arrhythmia, impaired hearing or blindness, severe hepatic or renal disease, on neuromuscular blocking agents, recent myocardial infarction, use of anti-psychotics, hypersensitivity to any of the drug under study.
Arms & Interventions
Dexmedetomidine
Inj.Dexmedetomidine(precidex ) 200mcg/2ml Given to participants in infusion form for 24 hours
Intervention: Dexmedetomidine Hydrochloride
Midazolam
Inj.midazolam 5mg/ml given to participants in infusion form for 24 hrs
Intervention: Dexmedetomidine Hydrochloride
Outcomes
Primary Outcomes
Effective sedation in icu patients lead to successful 1weaning in icu patients
Time Frame: Upto 48 hrs
Assess patients by using ramsay sedation score (score 1 =awake upto score 6=no response)