Efficacy of Dexmedetomidine Versus Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning
试验速览
- 阶段
- 早期 1 期
- 状态
- 尚未招募
- 入组人数
- 66
- 主要终点
- Effective sedation in icu patients lead to successful 1weaning in icu patients
研究概览
简要总结
Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression but also helps in weaning for early extubation,give hemodynamic stability and reduce morbidity and mortality in icu..
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •all patients with age <60 irrespective of gendre
排除标准
- •Patients who refuse to give consent, severely altered conscious level (GCS < 8/15), traumatic injury causing hypoxemia e.g., severe head / chest / facial trauma or pneumothorax, severe pneumonia, arrhythmia, impaired hearing or blindness, severe hepatic or renal disease, on neuromuscular blocking agents, recent myocardial infarction, use of anti-psychotics, hypersensitivity to any of the drug under study.
研究组 & 干预措施
Dexmedetomidine
Inj.Dexmedetomidine(precidex ) 200mcg/2ml Given to participants in infusion form for 24 hours
干预措施: Dexmedetomidine Hydrochloride (Drug)
Midazolam
Inj.midazolam 5mg/ml given to participants in infusion form for 24 hrs
干预措施: Dexmedetomidine Hydrochloride (Drug)
结局指标
主要结局
Effective sedation in icu patients lead to successful 1weaning in icu patients
时间窗: Upto 48 hrs
Assess patients by using ramsay sedation score (score 1 =awake upto score 6=no response)
次要结局
未报告次要终点
研究者
Momal Jaleel Khan
Dr.Momal jaleel khan
Sheikh Zayed Medical College