Evaluation of vancomycin pharmacokinetics in patients with augmented renal clearance

Phase 2

• Conditions: Augmented renal clearance.; Abnormal results of kidney function studies; R94.4

• Registration Number: IRCT20180802040665N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2021

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

Age over 18 years old
Need of vancomycin therapy with empirical approach or according to the culture
Augmented renal clearance (ARC) score between 7 and 10
Augmented renal clearance in trauma intensive (ARCTIC) score over than 6
Signing the informed consent form

Exclusion Criteria

Blood creatinine level lower than 1.5 mg/dL
Pregnant or breastfeeding patients
Patients with history of vancomycin hypersensitivity
Patients with history of vancomycin taking in the current course of hospitalization

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ratio of patients with Area under the curve (AUC)/Minimum inhibitory concentration (MIC) over 400. Timepoint: Three days after initiation of intervention. Method of measurement: High performance liquid chromatography.

Secondary Outcome Measures

Name	Time	Method
Blood trough level of vancomycin. Timepoint: Three days after initiation of intervention. Method of measurement: High performance liquid chromatography.;Getting acute kidney injury. Timepoint: Seven days after initiation of intervention. Method of measurement: Measurement of creatinine blood level.