application of high dose regimen of vancomycin in acute bacterial meningitis
Not Applicable
- Conditions
- meningitis.Bacterial meningitis, not elsewhere classified
- Registration Number
- IRCT201107233449N7
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Filling consent form; Patients with diagnosis of acute bacterial meningitis who are candidated for receiving vancomycin; Age=18 yrs; Not receive vancomycin in last 2weeks
Exclusion criteria: Clinical states which could change phahrmacokinetic of vancomycin (eg. burn, cystic fibrosis, edema); Pregnancy; Patients with CKD who need dialysis ; Contraindication for vancomycin
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum level of Cystatin-C. Timepoint: every other day. Method of measurement: mg/l.;Serum level of creatinine. Timepoint: every other day. Method of measurement: mg/dl.;Serum level of KIM-1. Timepoint: every other day. Method of measurement: pg/ml.;Serum level of vancomycin. Timepoint: third and 10th day. Method of measurement: mcg/ml.
- Secondary Outcome Measures
Name Time Method