The Effect of Ocular Surface Lubricant Eyedrops on Lid Parallel Conjunctival Folds (LIPCOF) and Other Signs and Symptoms of Dysfunctional Tear Syndrome

Ruprecht et al. (1976-78) were among the first to ask a general population a simple question: "do you have gritty sensation in your eyes?". The results have shown that in the age group 55-59, 22,8% females and 9,9% males reported this symptom. In the age group 45-54 years, almost 20% of females and 15% of males also had dry eye signs. Based on reported symptoms, Schirmer test, TBUT test or Rose Bengal Staining, Jacobssson et al. in their survey among 780 subjects belonging to general population in Sweden have found that prevalence of dry eye in the age group 55-72 years was 15%. In the more recent study by Hikichi et al. in Japan, which screened 2127 patients in eight medical centers, dry eye symptoms were found among 17% of them. No seasonal fluctuations were observed. Survey on 504 subjects aged 30-60 in Kopenhagen has revealed the prevalence of dry eye in 11% of them. In a larger study in Maryland, USA, involving 2520 residents older than 65, 15% reported one or more dry eye symptoms, but only 2.2% of them also had pathological Schirmer test.

Mentioned studies have shown that dry eye symptoms were most prevalent in the age group older than 50, although no correlation was found between the age and gender. McCarthy et al. analyzed the prevalence of dry eye in Melbourne (Australia). 926 participants older than 40 were enrolled in the survey. Dry eye was diagnosed in 10.8% of subjects by Rose Bengal staining, in 16.3% of them by Schirmer test, 8.6% by TBUT test, 1.5% by fluorescein staining, in 7.4 of subjects by using two or more tests, and in 5.5% of subjects with the extreme symptoms of dry eye unrelated to hay fever. Women reported dry eye symptoms more frequently than men. Canadian Dry Eye Epidemiology Study (CANDEES) tried to establish the prevalence of dry eye in Canada. Questionnaires were mailed to every optometrist in Canada, who were asked to hand them out to 30 consecutive patients. The total of 13.517 completed questionnaires were returned (15.6% of those sent out). All age groups were enrolled in the study. 55% of subjects were in the age group 21-50, 60.7% were women, and 24.3% of them wore contact lenses. Dry eye symptoms were reported by 28.7% of surveyed subjects. When asked to describe the severity of symptoms, 7.6% reported moderate but constant symptoms, while 1.6% of them described them as severe. It is interesting to note that the vast majority of subjects who reported having severe symptoms were women (ratio women to men: 46:1). Regarding gender, 33% of women and 22% of men reported dry eye symptoms. Salisbury Study (1997) found dry eye symptoms in 59% of surveyed subjects. In Beaver Dam Eye Study (2000) 14,4% out of 3703 surveyed subjects had dry eye symptoms11. Part of this study was to analyze possible association of dry eye symptoms with other parameters. Statistically significant and independent association was found between dry eye symptoms and arthritis, smoking, coffee drinking, hyperthyreosis, goiter, diabetes and taking multivitamin food supplements.

When analyzing causes of first visits to the general outpatient office in Zagreb University Hospital Eye Department, 6.3% of all patients reported dysfunctional tear syndrome symptoms as their primary cause for visit. That percentage rose to 48% when only patients with external eye disease symptoms were analyzed, and would no doubt be even higher if only chronic external eye inflammatory conditions were counted.

Group of authors led by Prof.Hoeh 1995 published the paper Lid-parallel conjunctival folds are a sure diagnostic sign of dry eye. The method described was named Lidkantenparallelen Konjunktivalen Falten, or Lid Parallel Conjunctival Folds (LIPCOF). It was presented as a very useful and innovative way of diagnosing dry eye. However, it was up till now mentioned in relatively few published papers and is rarely used in everyday clinical practice, especially outside Europe, where it is frequently termed conjunctivochalasis and not associated with dry eye.

According to authors, the height and/or number of bulbar conjunctival folds parallel to the temporal margin of the lower eyelid are observed. Before assessment, lower eyelid is briefly lifted from the eye surface- if folds disappear, they indeed are what is described as LIPCOF.