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临床试验/NCT06032585
NCT06032585已完成不适用

TRANSPARK_LONG: The Diagnostic Value of Early Transcranial Ultrasound in Patients With Extrapyramidal Diseases in a Swedish Population: an Evaluation in the Form of a Retrospective Cohort Study With a Long Follow-up Time

Region Skane1 个研究点 分布在 1 个国家目标入组 74 人开始时间: 2024年2月8日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
Region Skane
入组人数
74
试验地点
1
主要终点
Correlation

研究概览

简要总结

Popular science summary of the project The purpose of the study is to investigate in a Swedish population how well the investigators' previous ultrasound findings match the final diagnosis (PD, APS or ET) after a particularly long follow-up time, which greatly increases the certainty that the diagnosis does not change more and is thus correct. Furthermore, the investigators want to study whether the initial ultrasound findings have changed during the control interval and whether measurement results regarding the diameter in one of the fluid-filled rooms in the brain (third ventricle) can be correlated with the development of cognitive impairment or dementia later in the course of the disease. For this, this study have got ethical permission to go into the patients' medical records and to call a subgroup back to the clinic to be able to do a new examination and a memory test.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 100 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with parkinsonism or essential tremor who came into contact with our clinic before 2017
  • Satisfactory transcranial bone window
  • Previous TU (clinical indication)

排除标准

  • No transcranial bone window

结局指标

主要结局

Correlation

时间窗: over 7-10 yrs

Is hyperechogenicity of substantia nigra at mesencephal plane (measured bilaterally in mm2 by transcranial b-mode sonography correlated with a high percentage of patients with classical Parkinsons Disease in contrast to atypical parkinsonism patients?

次要结局

  • Correlation(7-10 (retrospective))

研究者

发起方
Region Skane
申办方类型
Other
责任方
Sponsor

研究点 (1)

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