Tomographic and Histological Evaluation of Postextraction Sockets Treated With Leucocyte- and Platelet-rich Fibrin: a Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Width resorption 1mm
研究概览
简要总结
The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 17 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(1) Health patients, American Society of Anesthesiologists (ASA) I or II
- •(2) Patients who need to submit tooth extraction (pre-molar, canine and incisor teeth - uniradicular teeth or teeth with fused roots) which present ideal conditions to receive dental implants after 3 months.
排除标准
- •Systemic diseases related with healing disorders
- •Poor oral hygiene
- •Pregnant or lactating patient
- •Use of flap elevation for dental extraction
研究组 & 干预措施
L-PRF group
The use of autologous leucocyte- and platelet-rich fibrin in alveolar sockets after dental extraction.
干预措施: Platelet-rich fibrin (Procedure)
Control
Conventional tooth extraction without any bone substitute.
结局指标
主要结局
Width resorption 1mm
时间窗: After 3 months
The ridge width differences between baseline and after three months of healing 1 mm below the crest.
次要结局
- Histological Analysis - fibrous tissue(After 3 months)
- Histological Analysis - bone cells(After 3 months)
- Histological Analysis - capillary vessels(After 3 months)
- Histological Analysis - new bone formation(After 3 months)
- Width resorption 3mm(After 3 months)
- Width resorption 5mm(After 3 months)
研究者
João Vitor dos Santos Canellas, DDS MS
PhD Student
Rio de Janeiro State University