Tomographic and Histological Evaluation of Postextraction Sockets Treated With Leucocyte- and Platelet-rich Fibrin: a Randomized Clinical Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bone Loss, Alveolar
- Sponsor
- Rio de Janeiro State University
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Width resorption 1mm
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The effect of leucocyte- and platelet-rich fibrin (L-PRF) for enhancing the healing after dental extractions is still a matter of debate. The available literature suggests that L-PRF performs positive effect to improve alveolar preservation resulting in less bone resorption on extraction sockets. L-PRF is a second generation of platelet concentrate produced without biochemical blood manipulation. L-PRF is composed by three key parameters: first, the presence of platelets; second, the presence of leucocytes; third, the density and complex organization of the fibrin matrix architecture produced by a natural polymerization process. The theory is that this key parameters acts to produce a faster bone healing.
Investigators
João Vitor dos Santos Canellas, DDS MS
PhD Student
Rio de Janeiro State University
Eligibility Criteria
Inclusion Criteria
- •(1) Health patients, American Society of Anesthesiologists (ASA) I or II
- •(2) Patients who need to submit tooth extraction (pre-molar, canine and incisor teeth - uniradicular teeth or teeth with fused roots) which present ideal conditions to receive dental implants after 3 months.
Exclusion Criteria
- •Systemic diseases related with healing disorders
- •Poor oral hygiene
- •Pregnant or lactating patient
- •Use of flap elevation for dental extraction
Outcomes
Primary Outcomes
Width resorption 1mm
Time Frame: After 3 months
The ridge width differences between baseline and after three months of healing 1 mm below the crest.
Secondary Outcomes
- Histological Analysis - fibrous tissue(After 3 months)
- Histological Analysis - bone cells(After 3 months)
- Histological Analysis - capillary vessels(After 3 months)
- Histological Analysis - new bone formation(After 3 months)
- Width resorption 3mm(After 3 months)
- Width resorption 5mm(After 3 months)