Detection of schistosoma CAA in travellers after high-risk water contact

Completed

• Conditions: Bilharzia; Schistosomiasis; 10019381

• Registration Number: NL-OMON45019
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 155

Inclusion Criteria

1. Any self-reported high risk water contact, including wading, showering, surfing, walking along wet shore bare-footed or washing with water from a high-risk source, within 2 years prior to reporting to the outpatient department
2. Agreement to perform routine diagnostic procedures to diagnose schistosomiasis infection
3. Willing to provide a maximum of three additional blood samples in addition to routine diagnostic procedures
4. Able to provide informed consent

Exclusion Criteria

1. Previous treatment for schistosomiasis
2. Known positive schistosomiasis serology before last high risk water contact
3. The use of immunosuppressive or immunomodulatory drugs at presentation that compromise the interpretation of schistosomiasis serology

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary endpoint:<br /><br>The sensitivity and specificity of urine UCP-CAA in travellers with reported<br /><br>high-risk water contact, as compared with routine diagnostics.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary endpoint:<br /><br>The percentage of travellers with persisting positive urine UCP-LF CAA six<br /><br>weeks after conventional praziquantel treatment</p><br>