Interrupting seasonal transmission of bilharzia and control of intestinal worm infections in northern and central Côte d’Ivoire

Not Applicable

Completed

• Conditions: Schistosoma haematobium infection; Infections and Infestations

• Registration Number: ISRCTN10926858
• Lead Sponsor: Swiss Tropical and Public Health Institute

Brief Summary

2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30890180 results 2018 Protocol article in https://pubmed.ncbi.nlm.nih.gov/29378542/ (added 23/04/2021) 2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33429843/ (added 23/04/2021) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/34519344/ (added 20/01/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-12-21
• Study Completion: 2019-02-28
• Last Update Posted: 30 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 58000

Inclusion Criteria

1. Children, females and males, aged 5-12 years
2. Adults, females and males, aged 20-55 years
3. Resident in one of the 60 villages in northern and central Côte d’Ivoire that are part of the study
4. Written informed consent signed by adults (aged 20-55 years) and parents/guardian of children (aged 5-12 years) and oral assent by children
5. Able and willing to provide single urine and stool samples during the annual cross-sectional surveys
6. No known allergy to study medication (i.e. praziquantel)

Exclusion Criteria

1. Children not aged 5-8 years or 9-12 years
2. Adults not aged 20-55 years
3. No written informed consent by adults, and parents/guardian on behalf of their children
4. Pregnancy in female participants
5. Known allergy to study medication (i.e. praziquantel)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence and intensity of S. haematobium infection is assessed using the standard urine filtration method and microscopy at baseline, 1, 2 and 3 years.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Snail abundance and infection rates are assessed using malacological surveys (i.e. searching for intermediate host snails by hand and with scoops for 15 min in a defined area of a natural open freshwater body) in arm 4 only at baseline, 1, 2 and 3 years<br> 2. Presence and number of intestinal helminth eggs will be assessed with the Kato-Katz method at baseline, 1, 2 and 3 years<br>