The evaluation of acute vascular damage induced by platinum-based chemotherapy
- Conditions
- gynecological cancer
- Registration Number
- JPRN-UMIN000012956
- Lead Sponsor
- Dept of Obstetrics and Gynecology, Osaka Medical College
- Brief Summary
The administration of TC induced hypertriglyceridemia in 2/3 of the participants, with that of bezafibrate reduced the serum TG levels. Meanwhile, the decrease in %FMD induced by TC improved following treatment with bezafibrate. The serum pentraxin-3 level increased rapidly after TC and decreased following bezafibrate treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 100
Not provided
Participants who had received prior treatment for cancer and those with a history of cardiovascular disease (myocardial infarction, stroke, peripheral arterial thrombosis) or decompensated diabetes were excluded from this study. The exclusion criteria also included a history of clinically significant gastrointestinal, liver or gallbladder disease, treatment with lipid- or glucose-lowering agents and the use of hormone replacement therapy within the previous one year.
Study & Design
- Study Type
- Interventional,observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change of the flow-mediated dilation (FMD), serum pentraxin-3
- Secondary Outcome Measures
Name Time Method