Studies on effects of medium-chain triglyceride (MCT) on physical function in elderly subjects.
Not Applicable
- Conditions
- Frail elderly subjects
- Registration Number
- JPRN-UMIN000023302
- Lead Sponsor
- Showa Women's University
- Brief Summary
Please see the following published paper: Abe S, Ezaki O, Suzuki M. Medium-chain triglycerides (8:0 and 10:0) are promising nutrients for sarcopenia: a randomized controlled trial. Am J Clin Nutr. 2019 Jul 23. pii: nqz138. doi: 10.1093/ajcn/nqz138. [Epub ahead of print] PubMed PMID: 31334544
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
Not provided
Exclusion Criteria
Exclusion criteria are subjects with treated with parenteral nutrition, or difficulty of swallowing, or type 1 diabetes mellitus, severe heart failure, liver, kidney, blood disease, or FBS > 200 mg/dl, or blood creatinine > 1.5 mg/dl or CRP > 2.0 mg/dl or BMI > 23 to avoid a further increase in body weight, or food allergy to supplements used in this study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Iteration numbers in legs open and close
- Secondary Outcome Measures
Name Time Method Muscle function (locomotive and respiratory) and cognitive function at baseline, during 3-mo intervention and at washout are measured. Mid-upper-arm muscle area (AMA) is estimated by measuring triceps skin fold thickness (TSF) and mid-upper-arm circumference (AC); strength in the upper extremities is measured by a handgrip dynamometry; strength in the lower extremities is estimated by the leg extension power. Muscle function is estimated by gait speed; swallowing ability is estimated by repetitive saliva swallowing test; strength of respiratory muscles is estimated by peak expiratory flow (PEF); ADL is estimated by Functional Independence Measure (FIM). Cognitive function is estimated by Mini-Mental State Examination (MMSE), NM scale, and Neuropsychiatric Inventory Nursing Home Version (NPI-NH).