Route and Adequacy of Nutrition and Outcomes of Haematopoietic Cell Transplantation in Patients With Haematological Neoplasms
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 484
- 主要终点
- Number of Participants With Acute Graft Versus Host Disease (GvHD) at Any Site (Grade II or Above) and Acute GvHD of the Gut of Any Grade
研究概览
简要总结
Retrospective case-note review to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation.
详细描述
This is a retrospective case-note review of adults undergoing haematopoietic cell transplantation to treat a haematological malignancy who have been admitted to Hammersmith Hospital from 2000 to 2014. All patients receiving an allogeneic haematopoietic cell transplant from a matched sibling or identically matched unrelated donor will be included. We will record the route and assess the broad adequacy of nutritional intakes to determine if nutrition via the enteral compared to the parenteral route results in better outcomes after haematopoietic cell transplantation. Our outcomes are graft versus host disease incidence and severity, transplant related (early) mortality and overall survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 17 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing their first HCT for a hematologic malignancy
- •Undergoing HCT using a sibling or unrelated donor
- •Undergoing HCT infusion between January 2000 and December 2014
排除标准
- •HCT using umbilical cord blood donors
- •HCT using haploidentical donors
结局指标
主要结局
Number of Participants With Acute Graft Versus Host Disease (GvHD) at Any Site (Grade II or Above) and Acute GvHD of the Gut of Any Grade
时间窗: 100 days after the date of hematopoietic cell infusion
Occurrence of acute GvHD at any site (grade II or above) and acute GvHD of the gut of any grade (graded according to standard criteria). Standard criteria to grade the severity of acute GvHD are quantification of rash, serum bilirubin and diarrhoea. These standard criteria have been developed and used for \> 20 years by most transplant centres to improve comparability between publications.
Non Relapse Mortality
时间窗: 100 days after the date of hematopoietic cell infusion
Defined as death without previous relapse
次要结局
- Graft Versus Host Disease-free and Relapse-free Survival(5 years after the date of hematopoietic cell infusion)
- 5 Year Survival(5 years after the date of hematopoietic cell infusion)
研究者
JBeckerson
Haemato-Oncology Specialist Dietitian
Imperial College Healthcare NHS Trust