System for Measuring Non-invasive Blood Flow in the Tracheobronchial Mucosa: Validation of Reproducibility
Not Applicable
Withdrawn
- Conditions
- Healthy
- Registration Number
- NCT01402752
- Lead Sponsor
- Centre Hospitalier Universitaire de Nīmes
- Brief Summary
The primary objective of this study is to evaluate the reproducibility of a method of measuring blood flow rates to the tracheo-bronchial mucosa using diluted dimethyl ether as a tracer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- The patient must have given his/her informed and signed consent
- The patient must be insured or beneficiary of a health insurance plan
Exclusion Criteria
- The patient is under judicial protection, under tutorship or curatorship
- The patient refuses to sign the consent
- It is impossible to correctly inform the patient
- Patient is pregnant
- Patient is breast feeding
- The patient is a smoker
- The patient has, or has a history of, chronic respiratory insufficiency
- The patient has a contra-indication for a treatment necessary in this study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The reproducibility of two measures of Qaw at a five minute interval Five minutes Qaw is the blood flow measured in the tracheobronchial mucosa. Qaw = VDME/(FDME\*alpha\*10s) where VDME is the volume of dimethyl-ether exhaled (ml), FDME is the mean concentration of dimethyl-ether (%), alpha is the Bunsen coefficient for the dissolution of dimethyl ether in tissues and blood at 37°C (i.e. 9ml/ml).
- Secondary Outcome Measures
Name Time Method The time necessary to complete one measure of Qaw (minutes) Day 1 Qaw = blood flow measured in the tracheobronchial mucosa