Top care for children with atopic dermatitis (and asthma) within the atopy syndroom, using the digital Eczema Centre WKZ- Dutch Asthma Centre Davos

Completed

• Conditions: asthma; 10014982; dermatitis; atopic dermatitis; 10006436

• Registration Number: NL-OMON40111
• Lead Sponsor: dermatologi'/allergologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 258

Inclusion Criteria

- severe atopic dermatitis (atopy syndrome); children who still need intensive multidisciplinary care after fulfilling the usual 2 or 3 consultations with the dermatologist and dermatology nurse
- 8-18 years
- able to speak and write in Dutch
- internet access and able to use the digital eczema centre Utrecht
-willingness for a stay of 6 weeks in the Dutch Asthma Centre Davos

Exclusion Criteria

- Participation in study 08-368; However, children and their parents can be asked to participate in this study after finishing study 08-368

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcomes for psychosocial study part are Coping and acceptance of the<br /><br>disease by the child.<br /><br>Primary outcome of clinical part of the study is disease activity of atopic<br /><br>dermatitis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Child: :<br /><br>- severity of asthma<br /><br>- self-esteem and feelings of competency<br /><br>- autonomy (for children of 12 years up)<br /><br>- anxiety<br /><br>- asthma -specific quality of life<br /><br>Parents:<br /><br>- stress<br /><br>- anxiety<br /><br>- disease-specific quality of life<br /><br><br /><br>Secundary study parameters that will be investigated in the translational study:<br /><br>- FeNO (NO in exhaled air)<br /><br>- Eosinophils<br /><br>- Total IgE<br /><br>- Specific IgE to (auto)-allergens<br /><br>- NO (nitric oxide) in serum<br /><br>- Profile of Th1 and Th2 cytokines in serum<br /><br>- OPN (osteopontin) in serum<br /><br>- TSLP (thymic stromal lymphopoietin) in serum<br /><br>- TSLP and protease activity in the superficial skin<br /><br>- Bacterial colonization of the skin<br /><br>- TSLP DNA polymorphism<br /><br><br /><br>Secundary parameters in this second amendement:<br /><br>- Bacterial colonization of the nose<br /><br>- Filaggrin mutations</p><br>