Combination of Antihypertensive therapy in the elderly, Multicenter Investigation <CAMUI> Multi-center randomized controlled study on efficacy of ARB/Diuretic mixture versus ARB/Ca channel blocker combination therapy to blood pressure or cognitive function in the elderly patients who have insufficient controlled hypertension in ARB monotherapy
Phase 4
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000001688
- Lead Sponsor
- Elderly Hypertension Conference
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with the secondary hypertension 2) Patients with heart failure: >= NYHA grade III 3) Patient with a history of severe renal disease: serum creatinine>= 2.0 mg/dl 4) Patients with critical liver damage: ALT or ASTis 3 times of normal upper level or more 5) Patients with a history of hypersensitivity to PREMINENT 6) Patients with a history of hypersensitivity to components of thiazide or similar compounds 7) Patients who are considered to be not eligible to the study by the investigator due to medical reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic/Diastolic blood pressure change during three month treatment.
- Secondary Outcome Measures
Name Time Method MMSE score change. The rate of achieving the target blood pressure. The change of laboratory test results, including as HbA1c, HOMA-R, FBS, UP, microalbuminuria, K, and uric acid. The rate of continued treatment and the compliance of the treatment. Rates of adverse experiences