The Effects of a Zeaxanthin Intervention on Visuomotor Function

Not Applicable

Completed

• Conditions: Behavior and Behavior Mechanisms
• Interventions: Dietary Supplement: combinatory supplement; Dietary Supplement: zeaxanthin

• Registration Number: NCT02017418
• Lead Sponsor: University of Georgia

Brief Summary

This study was designed to test whether two zeaxanthin formulations (supplements containing different nutritional compounds with zeaxanthin and omega fatty acids being the primary ingredients of interest) influenced visual motor function. Visual motor function refers to the processing speed of the visual system and how individuals respond behavioral to visual stimuli (e.g., reaction time).

Detailed Description

This study was designed to test whether two zeaxanthin formulations (supplements containing different nutritional compounds with zeaxanthin and omega fatty acids being the primary ingredients of interest) influenced visual motor function. Visual motor function refers to the processing speed of the visual system and how individuals respond behavioral to visual stimuli (e.g., reaction time).

Study Timeline

• Study Start: 2012-02
• Study First Submitted: 2013-12-16
• Study First Submitted QC: 2013-12-16
• Study First Posted: 2013-12-20
• Primary Completion: 2014-07
• Study Completion: 2014-07
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-26
• Last Update Posted: 2015-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

• Age: ≥18 and ≤ 40 years
• BMI: ≥ 20 and ≤ 30 kg/m2
• No anticipated changes in dieting habits (as relevant to the intake of xanthophylls and fats/oils).
• No anticipated surgical procedures.
• Willingness and ability to give written informed consent and willingness and ability to comply with the study requirements.
• Corrected visual acuity (ETDRS): better than 20/60 in the eye selected for the study

Exclusion Criteria

• Smokers
• Current or history of relevant ocular diseases (such as AMD) or other conditions e.g., lipid disorders.
• Inability to reliably perform macular pigment optical density measurements by "Heterochromatic Flicker Photometry" or any of the other ophthalmic tests of the study.
• Any condition likely to interfere with normal gastro-intestinal absorption of xanthophylls (e.g., digestive disorders: inflammatory bowel disease, ulcerative colitis, Crohn's, irritable bowel, etc. or lipid disorders including conditions such as hypercholesterolemia)
• Current use of xanthophyll containing supplements or use of xanthophyll containing supplements in the past 6 months (but excluding multivitamins containing lutein or zeaxanthin at low potency).
• Participation in any other study during last 1 month before study initiation.
• Known hypersensitivity or allergy to xanthophylls.
• Regular intake of medications or supplements, which the principal investigator deems likely to confound the study outcomes. These include diabetes medication and statins or any other drug/supplement to modulate cholesterol or fat digestion/absorption.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
combinatory supplement	combinatory supplement	placebo combinatory supplement
zeaxanthin	zeaxanthin	placebo zeaxanthin

Primary Outcome Measures

Name	Time	Method
Macular pigment optical density	one year	Increases in the amount of macular pigment measured in optical density units

Secondary Outcome Measures

Name	Time	Method
fixed reaction time	one year	reaction time to a stimulus fixed in space
variable reaction time	12-months	reaction time to a stimulus with a position that varies in space
coincidence anticipation	12-months	button press when a light stimulus of varying speeds reaches a specific point in a linear light array

Trial Locations

Locations (1)

Department of Psychology, UGA; 🇺🇸 Athens, Georgia, United States