Application and mechanism of transcutaneous auricular vagus nerve stimulation in disorder of consciousness after brain injury

Phase 1

Recruiting

• Conditions: disorder of consiousness

• Registration Number: ITMCTR2100005296
• Lead Sponsor: Hangzhou normal university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-20

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Aged >18years;
2. Subacute patients diagnosed as DOC by CRS-R;
3. No nerve stimulating drugs were used within 48 hours before enrollment;
4. No neuromuscular blocker was used within 24 hours before enrollment;
5. No facial or ear pain, no recent ear trauma, no metal implants, including pacemakers, no pregnancy.

Exclusion Criteria

1. Personal or family history of epileptic seizures, history of cardiovascular disease, history of developmental neurological or psychiatric disease;
2. Untreated brain edema;
3. Metal implants in the body;
4. Unstable vital signs;
5. MRI scan contraindications: such as claustrophobia.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified