NL-OMON42190
Completed
Not Applicable
Cerebral Blood Flow during hemodialysis. A [15O]H2O PET-CT pilot study comparing cerebral blood flow before, during and after hemodialysis - Cerebral Blood Flow during hemodialysis.
Interne geneeskunde, Nefrologie0 sites14 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- blood supply to the brain
- Sponsor
- Interne geneeskunde, Nefrologie
- Enrollment
- 14
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged 65 years or older on maintenance hemodialysis, of which at least 6 patients for a longer period of time (\>1years). The patients must have an arteriovenous fistula without recirculation as established by routine Transonic flow measurements. The hemoglobin value should be in the target range 6\.2\- 8 mmol/l since at least 1 month.
Exclusion Criteria
- •1\. The absence of informed consent. 2\. Diagnosis of dementia, hydrocephalus, history of raised intracranial pressure, significant (\>70%) carotid artery stenosis, end stage liver disease. 3\. Actively treated cancer. 4\. Actual hospital admission at timing of HD study session. 5\. Cochlear implants. 6\. Claustrophobia. 7\. MRI incompatible implants in the body (including prosthetic heart valves). 8 Pacemakers. 9\. Subcutaneous insulin infusion pomp. 10\. Any risk of having metal particles in the eyes due to manual work without proper eye protections. 11\. Tatoos containing red pigments that form a safety risk. 12\. The refusal to be informed of significant carotid artery stenosis (duplex) or structural brain abnormalities (MRI) that could be detected during the study.
Outcomes
Primary Outcomes
Not specified
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