Cidofovir for laryngeal papillomatosis
Phase 2
- Conditions
- recurrent respiratory papillomatosis
- Registration Number
- JPRN-jRCTs041180032
- Lead Sponsor
- YOSHIZAKI Tomokazu
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1. Laryngeal papillomatosis diagnosed by laryngeal fiber scope and histopathological examination.
2. Adequate organ function:
1) White blood cells > 2,500/mm3
2) Neutrophils > 1,250/mm3
3) Platelet > 75,000/mm3
4) GOT < 100 IU/L, ALT < 100IU/L
5) Serum creatinine < 1.5 mg/dL
3. Written informed consent
Exclusion Criteria
1.Renal dysfunction: serum createnin more than 1.5 mg/dL
2.Nephrotoxic drug administration
3.An allergy to cidofovir
4.An allergy to probenecid or sulfa drug
5.Pregnant, unwilling to practice contraception during the study, or lactating female
6.Inappropriate decided by doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method